SCHEMBL27596372

SCHEMBL27596372

Cc1coc(CN(Cc2ccc(CNC(=O)c3ccncc3Cl)cc2)C2CCCc3cccnc32)n1

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 19/20 0.43
CYP3A4 P08684 7/20 0.42
CYP2D6 P10635 7/20 0.42
HDAC1 Q13547 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27529302 0.94 CXCR4 (0.43) CXCR4CYP3A4CYP2D6
SCHEMBL27529284 0.94 CXCR4 (0.41) CXCR4CYP3A4CYP2D6
SCHEMBL5051542 0.92 CXCR4 (0.43) CXCR4CYP3A4CYP2D6HDAC1HDAC6
SCHEMBL27596374 0.89 CXCR4 (0.43) CXCR4CYP3A4CYP2D6
SCHEMBL27510217 0.89 CXCR4 (0.40) CXCR4CYP3A4CYP2D6
SCHEMBL27578501 0.88 CXCR4 (0.43) CXCR4CYP3A4CYP2D6HDAC1HDAC6
SCHEMBL27578505 0.88 CXCR4 (0.46) CXCR4CYP3A4CYP2D6HDAC1HDAC6
SCHEMBL4063373 0.86 CXCR4 (0.40) CXCR4CYP3A4CYP2D6
SCHEMBL4065743 0.86 CXCR4 (0.44) CXCR4CYP3A4CYP2D6
SCHEMBL27596373 0.86 CXCR4 (0.43) CXCR4CYP3A4CYP2D6HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1458929-A Chemokine receptor binding heterocyclic compounds ANORMED INC (CA) 2003-11-26 CN disclosed