Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.81 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.81 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.81 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.81 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | XIAP | P98170 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48857 | 0.89 | PIK3CG (1.00) | PIK3CAPIK3CGPIK3CDPIK3CBAOC3 | |
| SCHEMBL48623 | 0.84 | PIK3CD (0.72) | PIK3CAPIK3CGPIK3CDPIK3CBXIAP | |
| SCHEMBL1786144 | 0.82 | PIK3CD (0.66) | PIK3CAPIK3CGPIK3CDPIK3CBMEN1 | |
| SCHEMBL1786138 | 0.82 | PIK3CD (0.66) | PIK3CAPIK3CGPIK3CDPIK3CBMEN1 | |
| SCHEMBL48850 | 0.82 | PIK3CD (0.69) | PIK3CAPIK3CGPIK3CDPIK3CBMEN1 | |
| SCHEMBL48762 | 0.82 | PIK3CD (0.67) | PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL1784577 | 0.82 | PIK3CD (0.69) | PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL48835 | 0.82 | PIK3CD (0.81) | PIK3CAPIK3CGPIK3CDPIK3CBXIAP | |
| SCHEMBL27656677 | 0.80 | PIK3CG (0.56) | PIK3CAPIK3CGPIK3CDPIK3CBMEN1 | |
| SCHEMBL48391 | 0.80 | PIK3CG (1.00) | PIK3CAPIK3CGPIK3CDPIK3CBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100548996-C | 5-phenylthiazole derivatives and their use for the preparation of medicaments | NOVARTIS AG (CH) | 2009-10-14 | — | — | CN | disclosed |
| CN-1639139-A | 5-phenylthiazole derivatives and use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2005-07-13 | — | — | CN | disclosed |