Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842278 | 0.87 | MAPT (0.54) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL5842206 | 0.86 | MAPT (0.53) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL5842917 | 0.86 | MAPT (0.53) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL5841644 | 0.86 | MAPT (0.61) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL5842506 | 0.86 | MAPT (0.53) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL5842465 | 0.85 | NPSR1 (0.56) | ALDH1A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL27617658 | 0.84 | MEN1 (0.62) | POLBKDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL5841789 | 0.83 | SMN1; SMN2 (0.58) | POLBALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL5841833 | 0.82 | MAPT (0.53) | POLBALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL5842953 | 0.81 | TP53 (0.61) | POLBALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100534990-C | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-02 | — | — | CN | claimed |
| CN-1610678-A | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS LTD (CH) | 2005-04-27 | — | — | CN | claimed |
| CN-100534990-C | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-02 | — | — | CN | disclosed |
| CN-1610678-A | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS LTD (CH) | 2005-04-27 | — | — | CN | disclosed |