Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27600691 | 1.00 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL27619127 | 1.00 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3551555 | 0.89 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3543809 | 0.89 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3551721 | 0.89 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL27600769 | 0.87 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27600688 | 0.87 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27619126 | 0.87 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3546697 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3548834 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1604776-A | 4-4-alkoxy-3-hydroxyphenyl-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes | MEMORY PHARM CORP (US) | 2005-04-06 | — | — | CN | claimed |
| CN-1604776-A | 4-4-alkoxy-3-hydroxyphenyl-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes | MEMORY PHARM CORP (US) | 2005-04-06 | — | — | CN | disclosed |