Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224578 | 0.84 | KDM4E (0.44) | MDM4TP53MDM2NAMPTHDAC1 | |
| SCHEMBL5229928 | 0.82 | NAMPT (0.43) | MDM4TP53MDM2NAMPTHDAC1 | |
| SCHEMBL5228223 | 0.82 | MDM4 (0.62) | MDM4TP53MDM2NAMPTHDAC1 | |
| SCHEMBL14885229 | 0.81 | MEN1 (0.57) | MDM4TP53MDM2NAMPTHDAC1 | |
| SCHEMBL5225778 | 0.81 | MEN1 (0.47) | MDM4TP53MDM2NAMPTHDAC1 | |
| SCHEMBL2829176 | 0.81 | POLB (0.56) | MDM4TP53NAMPTHDAC1MEN1 | |
| SCHEMBL22874499 | 0.80 | P4HTM (0.65) | MEN1KMT2AAHRP4HTM | |
| SCHEMBL24890664 | 0.79 | HDAC1 (0.53) | MDM4TP53MDM2NAMPTHDAC1 | |
| SCHEMBL22874503 | 0.79 | MEN1 (0.57) | MDM4TP53MDM2NAMPTHDAC1 | |
| SCHEMBL2385003 | 0.79 | MEN1 (0.48) | MDM4TP53MDM2NAMPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1662236-A | Inhibitors of histone deacetylase | ASTRAZENECA AB (SE) | 2005-08-31 | — | — | CN | disclosed |