SCHEMBL27607828

SCHEMBL27607828

Cc1ccccc1-c1c(Nc2ncc(C(=O)c3cnc(Nc4cccc(C(F)(F)F)c4-c4ccccc4C)s3)s2)cccc1C(F)(F)F

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
HTT P42858 3/20 0.46
NPC1 O15118 3/20 0.46
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 1/20 0.46
PLA2G1B P04054 1/20 0.46
MAPT P10636 1/20 0.46
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
ATG4B Q9Y4P1 1/20 0.46
MAPK14 Q16539 6/20 0.45
MAPK13 O15264 5/20 0.45
MAPK12 P53778 5/20 0.45
MAPK11 Q15759 5/20 0.45
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 1/20 0.44
LCK P06239 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5635191 0.81 MAPK13 (0.56) RAB9ASMN1; SMN2HTTNPC1ALDH1A1
SCHEMBL5634355 0.73 NPC1 (0.72) RAB9ASMN1; SMN2HTTNPC1ALDH1A1
SCHEMBL5634604 0.73 MAPK13 (0.59) RAB9ASMN1; SMN2HTTNPC1ALDH1A1
SCHEMBL5634110 0.71 MAPK13 (0.67) RAB9ASMN1; SMN2HTTNPC1ALDH1A1
SCHEMBL5635186 0.70 NPC1 (0.64) RAB9ASMN1; SMN2NPC1MAPK14MAPK13
SCHEMBL5634397 0.69 MAPK13 (0.74) RAB9ASMN1; SMN2HTTNPC1ALDH1A1
SCHEMBL5633869 0.69 MAPK13 (0.54) RAB9ASMN1; SMN2NPC1MAPK14MAPK13
SCHEMBL774143 0.69 LCK (0.72) MAPK14MAPK13MAPK12MAPK11LCK
SCHEMBL5634502 0.68 MAPK13 (0.54) RAB9ASMN1; SMN2HTTNPC1ALDH1A1
SCHEMBL5635687 0.68 MAPK13 (0.51) RAB9ASMN1; SMN2HTTNPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100381429-C Thiazole derivatives HOFFMANN LA ROCHE (CH) 2008-04-16 CN disclosed
CN-1675188-A Thiazole derivatives HOFFMANN LA ROCHE (CH) 2005-09-28 CN disclosed