Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nisoldipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 10/20 | 0.98 |
| ▸ | CACNA1F known ✓ | O60840 | 9/20 | 0.98 |
| ▸ | CACNA1D known ✓ | Q01668 | 9/20 | 0.98 |
| ▸ | CACNA1S known ✓ | Q13698 | 9/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.98 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.98 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.98 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.98 |
| ▸ | SCN1A | P35498 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.98 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.98 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.98 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nisoldipine SCHEMBL19348996 | 0.99 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL39779 | 0.99 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL39780 | 0.99 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL29420725 | 0.99 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL1172989 | 0.99 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL919020 | 0.98 | CACNA1C (0.98) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL3855961 | 0.98 | CACNA1C (0.98) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL4608536 | 0.95 | CACNA1D (0.92) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9765770 | 0.92 | CACNA1C (0.86) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7432246 | 0.91 | CACNA1C (0.84) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114939166-B | Application of calcium ion channel inhibitor in preparation of hantavirus infection resisting medicine | 中国人民解放军空军军医大学 | 2023-05-16 | — | — | CN | disclosed |
| CN-114939166-A | Application of calcium ion channel inhibitor in preparation of medicine for resisting hantavirus infection | 中国人民解放军空军军医大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-1569777-A | Chiral source and pharmaceutical salt or complex of organic alkali drug | GAO BINGYUAN (CN) | 2005-01-26 | — | — | CN | disclosed |