Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SNR3C2
The experimentally established mechanism targets of Nimodipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 9/20 | 0.81 |
| ▸ | CACNA1F known ✓ | O60840 | 8/20 | 0.81 |
| ▸ | CACNA1D known ✓ | Q01668 | 8/20 | 0.81 |
| ▸ | CACNA1S known ✓ | Q13698 | 8/20 | 0.81 |
| ▸ | MEN1 | O00255 | 5/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.98 |
| ▸ | MAPT | P10636 | 3/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.98 |
| ▸ | THPO | P40225 | 2/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.70 |
| ▸ | MLNR | O43193 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nimodipine SCHEMBL8531069 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nimodipine SCHEMBL29382758 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nimodipine SCHEMBL4530304 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nimodipine SCHEMBL34041 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| (S)-Nimodipine SCHEMBL34042 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nimodipine SCHEMBL30425942 | 0.99 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nimodipine SCHEMBL27757251 | 0.98 | MEN1 (0.98) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nimodipine SCHEMBL142534 | 0.98 | MEN1 (0.98) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nimodipine SCHEMBL28487234 | 0.96 | MEN1 (0.94) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| Nimodipine SCHEMBL26110731 | 0.96 | MEN1 (0.94) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102406595-B | Floating microorganism adhesive porous hydrogel and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL | 2013-05-29 | — | — | CN | claimed |
| CN-102406595-B | Floating microorganism adhesive porous hydrogel and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL | 2013-05-29 | — | — | CN | disclosed |
| CN-102406595-A | Floating bioadhesive porous hydrogel and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL | 2012-04-11 | — | — | CN | disclosed |
| CN-1569777-A | Chiral source and pharmaceutical salt or complex of organic alkali drug | GAO BINGYUAN (CN) | 2005-01-26 | — | — | CN | disclosed |