Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | PPARD | Q03181 | 6/20 | 0.36 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL27662212 | 1.00 | — | — | |
| Propionic Acid SCHEMBL30292602 | 0.96 | FFAR3 (0.83) | FFAR3TSHRALDH1A1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL29226970 | 0.96 | FFAR3 (0.83) | FFAR3TSHRALDH1A1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL4381008 | 0.96 | — | — | |
| Propionic Acid SCHEMBL29140109 | 0.92 | — | — | |
| Propionic Acid SCHEMBL28185010 | 0.92 | — | — | |
| Propionic Acid SCHEMBL10963259 | 0.92 | — | — | |
| Propionic Acid SCHEMBL27662193 | 0.92 | — | — | |
| Propionic Acid SCHEMBL31468939 | 0.92 | FFAR3 (0.91) | FFAR3TSHRALDH1A1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL127355 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101272807-A | Methods for treatment and prevention of otitis media using nonionic surfactants to facilitate transmembrane drug delivery to the middle ear | PIEDMONT PHARMACEUTICALS LLC (US) | 2008-09-24 | — | — | CN | disclosed |
| CN-101272772-A | Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery intothe middle ear | PIEDMONT PHARMACEUTICALS LLC (US) | 2008-09-24 | — | — | CN | disclosed |
| CN-1674870-A | Liposomes containing biologically active compounds | PIEDMONT PHARMACEUTICALS LLC (US) | 2005-09-28 | — | — | CN | disclosed |