Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 7/20 | 0.49 |
| ▸ | BCL6 | P41182 | 4/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27612425 | 0.88 | EGFR (0.53) | SCN9ASYKBTKEGFRKCNQ3 | |
| SCHEMBL2302190 | 0.83 | SCN9A (0.58) | SCN9ASYK | |
| SCHEMBL2103835 | 0.82 | BCL6 (0.60) | SYKBCL6NCOR2EGFRITK | |
| SCHEMBL27612600 | 0.76 | SYK (0.66) | SYKBCL6EGFRITK | |
| SCHEMBL12519774 | 0.75 | MAPK1 (0.54) | SYKEGFRITK | |
| SCHEMBL2061066 | 0.75 | ALK (0.55) | SCN9A | |
| SCHEMBL657489 | 0.74 | POLB (0.53) | SYKBCL6NCOR2EGFRPTK2 | |
| SCHEMBL658038 | 0.73 | BCL6 (0.71) | SYKBCL6NCOR2EGFRERBB2 | |
| SCHEMBL267189 | 0.72 | EGFR (0.50) | SCN9ASYKBTKEGFR | |
| SCHEMBL27631540 | 0.71 | SYK (0.54) | SYKBCL6NCOR2EGFRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |