Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | ITK | Q08881 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631873 | 0.90 | SYK (0.65) | SYKEGFRITKAURKABTK | |
| SCHEMBL27612448 | 0.90 | SYK (0.64) | SYKEGFRITKAURKA | |
| SCHEMBL656540 | 0.87 | AURKA (0.69) | SYKEGFRITKAURKABTK | |
| SCHEMBL27612806 | 0.86 | SYK (0.67) | SYKAURKA | |
| SCHEMBL27631681 | 0.85 | AURKA (0.74) | SYKAURKA | |
| SCHEMBL655756 | 0.83 | SYK (0.72) | SYKEGFRITKAURKA | |
| SCHEMBL27631904 | 0.82 | SYK (0.62) | SYKAURKA | |
| SCHEMBL656788 | 0.82 | SYK (0.65) | SYKEGFRITKAURKA | |
| SCHEMBL28757141 | 0.82 | SYK (0.61) | SYKAURKA | |
| SCHEMBL27631528 | 0.81 | SYK (0.78) | SYKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |