Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378376 | 0.77 | CYP17A1 (0.54) | GABRA5HDAC1NAMPTHDAC10HDAC6 | |
| SCHEMBL30159605 | 0.76 | KCNA5 (0.56) | KDM4AHDAC1KCNA5IDO1NAMPT | |
| SCHEMBL8018113 | 0.76 | KCNA5 (0.56) | KDM4AHDAC1KCNA5IDO1NAMPT | |
| SCHEMBL25551904 | 0.75 | CKS1B (0.51) | CKS1BSKP1SKP2GABRA5CYP1A2 | |
| SCHEMBL30036979 | 0.73 | CKS1B (0.49) | CKS1BSKP1SKP2GABRA5CYP1A2 | |
| SCHEMBL25551937 | 0.73 | CKS1B (0.49) | CKS1BSKP1SKP2GABRA5CYP1A2 | |
| SCHEMBL1691047 | 0.73 | HDAC1 (0.67) | KDM4AHDAC1NAMPTMEN1NPC1 | |
| SCHEMBL2121025 | 0.72 | SMN1; SMN2 (0.53) | CYP1A2KDM4ANPC1GAARAB9A | |
| SCHEMBL28129413 | 0.72 | NAMPT (0.58) | CKS1BSKP1SKP2HDAC1NAMPT | |
| SCHEMBL28646590 | 0.72 | HDAC1 (0.59) | KDM4AHDAC1KCNA5CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1617858-A | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-1) | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | CN | disclosed |