Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.59 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | ITK | Q08881 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631825 | 0.93 | SYK (0.59) | SYKEGFRITKCDK2CCNT1 | |
| SCHEMBL28753647 | 0.91 | SYK (0.60) | SYKEGFRITKCDK2CCNT1 | |
| SCHEMBL27612739 | 0.84 | SYK (0.60) | SYKEGFRITKCDK2CCNT1 | |
| SCHEMBL27631878 | 0.84 | SYK (0.60) | SYKEGFRITKCDK2CCNT1 | |
| SCHEMBL655497 | 0.80 | SYK (0.59) | SYKEGFRITKCDK2CCNT1 | |
| SCHEMBL656426 | 0.79 | SYK (0.61) | SYKEGFRITKCDK2AURKA | |
| SCHEMBL657309 | 0.77 | SYK (0.69) | SYKEGFRITKCDK2AURKA | |
| SCHEMBL655466 | 0.77 | SYK (1.00) | SYKITKCDK2AURKAPLK4 | |
| SCHEMBL657833 | 0.76 | SYK (0.58) | SYKEGFRITKAURKAJAK2 | |
| SCHEMBL28757133 | 0.76 | SYK (0.58) | SYKEGFRITKAURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |