Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 10/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL657262 | 0.88 | BCL6 (0.55) | BCL6EGFRITKNCOR2ALDH1A1 | |
| SCHEMBL656063 | 0.76 | EGFR (0.69) | BCL6EGFRITKNCOR2AURKA | |
| SCHEMBL27631624 | 0.75 | BCL6 (0.49) | BCL6EGFRITKNCOR2ALDH1A1 | |
| SCHEMBL655906 | 0.74 | SYK (0.65) | EGFRITKJAK3BTKAURKA | |
| SCHEMBL653516 | 0.71 | BCL6 (0.59) | BCL6EGFRITKNCOR2ALDH1A1 | |
| SCHEMBL657143 | 0.70 | SYK (0.78) | BCL6EGFRITKNCOR2AURKA | |
| SCHEMBL655720 | 0.70 | SYK (0.76) | EGFRITKAURKA | |
| SCHEMBL656282 | 0.70 | SYK (0.76) | EGFRITKAURKA | |
| SCHEMBL655513 | 0.70 | SYK (0.78) | BCL6EGFRITKNCOR2AURKA | |
| SCHEMBL656233 | 0.70 | SYK (0.60) | BCL6EGFRITKNCOR2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |