Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.68 |
| ▸ | AURKA | O14965 | 6/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
| ▸ | BCL6 | P41182 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631920 | 0.93 | SYK (0.68) | SYKAURKAEGFRITKBCL6 | |
| SCHEMBL656442 | 0.90 | EGFR (0.61) | SYKAURKAEGFRITKBCL6 | |
| SCHEMBL27631462 | 0.83 | AURKA (0.70) | SYKAURKAEGFRITKMAPK8 | |
| SCHEMBL655466 | 0.82 | SYK (1.00) | SYKAURKAITKMAPK8MAPK9 | |
| SCHEMBL657532 | 0.82 | EGFR (0.61) | SYKAURKAEGFRITKMAPK8 | |
| SCHEMBL656368 | 0.82 | EGFR (0.61) | SYKAURKAEGFRITKBCL6 | |
| SCHEMBL655117 | 0.77 | SYK (0.64) | SYKAURKAEGFRITKMAPK8 | |
| SCHEMBL654783 | 0.77 | SYK (0.78) | SYKAURKAEGFRITKMAPK8 | |
| SCHEMBL655501 | 0.77 | SYK (0.67) | SYKAURKAEGFRITK | |
| SCHEMBL655796 | 0.77 | SYK (0.67) | SYKAURKAEGFRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |