Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15328342 | 0.95 | PRMT1 (0.41) | PRMT1EPHX1KDM4EMAPK1HIF1A | |
| SCHEMBL18886309 | 0.82 | PRMT1 (0.58) | PRMT1EPHX1KDM4EMAPK1HIF1A | |
| SCHEMBL3174690 | 0.82 | KDM4E (0.50) | PRMT1EPHX1KDM4EMAPK1HIF1A | |
| SCHEMBL27615006 | 0.79 | EPHX1 (0.71) | EPHX1SMN1; SMN2ALDH1A1EPHX2HTT | |
| SCHEMBL2029681 | 0.79 | KDM4E (0.55) | PRMT1EPHX1KDM4EMAPK1HIF1A | |
| SCHEMBL28569684 | 0.79 | KDM4E (0.55) | PRMT1EPHX1KDM4EMAPK1HIF1A | |
| SCHEMBL453216 | 0.79 | KDM4E (0.55) | PRMT1EPHX1KDM4EMAPK1HIF1A | |
| SCHEMBL20836564 | 0.79 | KDM4E (0.55) | PRMT1EPHX1KDM4EMAPK1HIF1A | |
| SCHEMBL30541972 | 0.79 | KDM4E (0.55) | PRMT1EPHX1KDM4EMAPK1HIF1A | |
| SCHEMBL5569558 | 0.79 | KDM4E (0.55) | PRMT1EPHX1KDM4EMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |