Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 19/20 | 0.61 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.61 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.61 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.61 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.61 |
| ▸ | LPAR3 | Q9UBY5 | 12/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761301 | 0.92 | LPAR1 (0.70) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL14778130 | 0.92 | LPAR1 (0.70) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL343072 | 0.91 | LPAR1 (0.64) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL343071 | 0.91 | LPAR1 (0.64) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL12973640 | 0.91 | LPAR1 (0.72) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL343829 | 0.90 | LPAR1 (0.54) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL343828 | 0.90 | LPAR1 (0.54) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL343638 | 0.85 | LPAR1 (0.79) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL343639 | 0.85 | LPAR1 (0.79) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2761475 | 0.85 | LPAR1 (0.45) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141768-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141768-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |