Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 6/20 | 0.36 |
| ▸ | CCR3 | P51677 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 6/20 | 0.33 |
| ▸ | HAT1 | O14929 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615576 | 0.81 | KDM4E (0.39) | KDM4EHRH1CCR3KCNH2POLB | |
| SCHEMBL3282624 | 0.78 | KDM4E (0.52) | KDM4EHRH1CCR3KCNH2POLB | |
| SCHEMBL27596952 | 0.72 | — | — | |
| SCHEMBL2922360 | 0.71 | KDM4E (0.56) | KDM4EPOLBTDP1L3MBTL1HSD17B10 | |
| SCHEMBL2916302 | 0.70 | KDM4E (0.54) | KDM4EPOLBTDP1L3MBTL1HSD17B10 | |
| SCHEMBL2920920 | 0.70 | KDM4E (0.54) | KDM4EHRH1CCR3POLBL3MBTL1 | |
| SCHEMBL2922964 | 0.70 | KDM4E (0.54) | KDM4EHRH1CCR3KCNH2POLB | |
| SCHEMBL2923292 | 0.70 | KDM4E (0.50) | KDM4EHRH1CCR3KCNH2POLB | |
| SCHEMBL2913348 | 0.67 | KDM4E (0.50) | KDM4EHRH1CCR3KCNH2POLB | |
| SCHEMBL3282678 | 0.66 | PARG (0.50) | KDM4EHRH1CCR3KCNH2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100564358-C | The method of a kind of preparation 4-(3, the 4-dichlorophenoxy) piperidines | ASTRAZENECA AB (SE) | 2009-12-02 | — | — | CN | disclosed |
| CN-100352807-C | substituted piperidine compounds | ASTRAZENECA AB (SE) | 2007-12-05 | — | — | CN | disclosed |
| CN-1907968-A | Method for making 4-(3,4-dichlorophenoxy)piperidine | ASTRAZENECA AB (SE) | 2007-02-07 | — | — | CN | disclosed |
| CN-1633414-A | Compound (I) | ASTRAZENECA AB (SE) | 2005-06-29 | — | — | CN | disclosed |