Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341660 | 0.83 | NOTUM (0.43) | NOTUMHRH3KCNH2KDM4ELMNA | |
| SCHEMBL16356986 | 0.72 | NOTUM (0.50) | NOTUMHRH3KCNH2DPP8DPP9 | |
| SCHEMBL27593301 | 0.70 | NR1H2 (0.50) | NOTUMHRH3KDM4ELMNAMAPT | |
| Hydrochloric Acid SCHEMBL6986390 | 0.70 | HRH3 (0.51) | NOTUMHRH3KCNH2KDM4ELMNA | |
| SCHEMBL13542496 | 0.70 | NOTUM (0.47) | NOTUMHRH3KCNH2LMNATSHR | |
| SCHEMBL1101990 | 0.69 | MEN1 (0.55) | NOTUMHRH3KCNH2KDM4ELMNA | |
| SCHEMBL9442654 | 0.69 | MEN1 (0.47) | NOTUMHRH3KCNH2KDM4ELMNA | |
| SCHEMBL7915917 | 0.69 | NOTUM (0.55) | NOTUMHRH3KCNH2DPP8DPP9 | |
| SCHEMBL14452891 | 0.69 | NOTUM (0.50) | NOTUMHRH3KCNH2TSHRDPP8 | |
| SCHEMBL8210707 | 0.69 | NOTUM (0.50) | NOTUMHRH3KCNH2TSHRDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1759118-B | Diazepinoindole derivatives as kinase inhibitors | PFIZER | 2010-12-08 | — | — | CN | disclosed |
| CN-1759118-A | Diazepinoindole derivatives as kinase inhibitors | PFIZER (US) | 2006-04-12 | — | — | CN | disclosed |