Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 14/20 | 0.67 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4343925 | 0.86 | MAOB (0.65) | MAOBNR4A2PARP10MAOAKDM4E | |
| SCHEMBL157732 | 0.86 | MAOB (0.65) | MAOBNR4A2PARP10PPARAMAOA | |
| SCHEMBL27521276 | 0.84 | MAOB (0.77) | MAOBNR4A2PARP10MAOA | |
| SCHEMBL22874578 | 0.82 | MAOB (0.60) | MAOBNR4A2PARP10MAOAKDM4E | |
| SCHEMBL22874577 | 0.82 | MAOB (0.60) | MAOBNR4A2PARP10MAOAKDM4E | |
| SCHEMBL3625818 | 0.81 | MAOB (0.73) | MAOBNR4A2PARP10MAOALMNA | |
| SCHEMBL15171108 | 0.81 | MAOB (0.73) | MAOBNR4A2PARP10MAOA | |
| SCHEMBL11959694 | 0.81 | MAOB (0.72) | MAOBNR4A2PARP10MAOA | |
| SCHEMBL21340832 | 0.80 | MAOB (0.79) | MAOBNR4A2PARP10MAOA | |
| SCHEMBL22874674 | 0.80 | MAOB (0.71) | MAOBNR4A2PARP10MAOAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100503562-C | Pyrrolidone derivatives as MAOB inhibitors | HOFFMANN LA ROCHE (CH) | 2009-06-24 | — | — | CN | disclosed |
| CN-100482638-C | N-acylaminobenzene dervatives as selective monoamine oxidase b inhibitors | HOFFMANN LA ROCHE (CH) | 2009-04-29 | — | — | CN | disclosed |
| CN-1681777-A | Pyrrolidone derivatives as MAOB inhibitors | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | CN | disclosed |
| CN-1656057-A | N-acylaminobenzene dervatives as selective monoamine oxidase b inhibitors | HOFFMANN LA ROCHE (CH) | 2005-08-17 | — | — | CN | disclosed |