Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 10/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488979 | 0.82 | MAP4K4 (0.54) | PIK3CGPIK3CDPIK3CAPI4KBFYN | |
| SCHEMBL2762153 | 0.80 | PIK3CG (0.58) | PIK3CGPIK3CDPIK3CAPIK3CBGPR55 | |
| SCHEMBL2762387 | 0.80 | PIK3CG (0.58) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| SCHEMBL17795259 | 0.77 | PIK3CG (0.52) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL2762072 | 0.76 | PIK3C3 (0.53) | PIK3CGPIK3CDPIK3CAPI4KBPIK3C3 | |
| SCHEMBL16836034 | 0.75 | PIK3CD (0.51) | PIK3CGPIK3CDGPR55CYP11B2MAP4K4 | |
| SCHEMBL5700416 | 0.75 | PIK3CG (0.50) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL30565567 | 0.74 | KDM4E (0.64) | PIK3CAFYNMAP4K4MINK1TNIK | |
| SCHEMBL597932 | 0.74 | KDM4E (0.64) | PIK3CAFYNMAP4K4MINK1TNIK | |
| SCHEMBL21753325 | 0.73 | PIK3CG (0.49) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010092015-A1 | UREA TRIAZOLOLO [1, 5-A] PYRIDINE DERIVATIVES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010092015-A1 | UREA TRIAZOLOLO [1, 5-A] PYRIDINE DERIVATIVES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |