Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.73 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL373105 | 0.87 | KDM4E (1.00) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL29631004 | 0.87 | KDM4E (1.00) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL193466 | 0.86 | KDM4E (0.73) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL359879 | 0.86 | KDM4E (0.73) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL9374034 | 0.86 | KDM4E (0.73) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL5903774 | 0.84 | HDAC1 (1.00) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL3094136 | 0.82 | HDAC6 (0.70) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL8567491 | 0.82 | HDAC1 (0.77) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL1258592 | 0.82 | KDM4E (0.67) | KDM4EHDAC1HDAC4HDAC6HDAC3 | |
| SCHEMBL7902381 | 0.82 | KDM4E (0.67) | KDM4EHDAC1HDAC4HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | claimed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | claimed |
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | disclosed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | disclosed |