Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Topotecan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 19/20 | 0.95 |
| ▸ | MEN1 | O00255 | 5/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.95 |
| ▸ | CASP1 | P29466 | 3/20 | 0.95 |
| ▸ | CASP7 | P55210 | 3/20 | 0.95 |
| ▸ | HBB | P68871 | 3/20 | 0.95 |
| ▸ | MAPT | P10636 | 3/20 | 0.95 |
| ▸ | USP2 | O75604 | 2/20 | 0.95 |
| ▸ | LMNA | P02545 | 2/20 | 0.95 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.95 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.95 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.95 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.94 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.94 |
| ▸ | TOP2A | P11388 | 1/20 | 0.94 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.94 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Topotecan SCHEMBL1231036 | 0.99 | TOP1 (0.95) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL29375999 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL7248 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL10588295 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL29742318 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL418714 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL7247 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL10278 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL7056079 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL27326849 | 0.98 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100372854-C | Process for the preparation of topotecan from 10-hydroxy-20- -camptothecin | COUNCIL SCIENT IND RES (IN) | 2008-03-05 | — | — | CN | claimed |
| CN-1764663-A | Method for preparing topotecan from 10-hydroxy-4-(S)-camptothecine | COUNCIL SCIENT IND RES (IN) | 2006-04-26 | — | — | CN | claimed |
| CN-100372854-C | Process for the preparation of topotecan from 10-hydroxy-20- -camptothecin | COUNCIL SCIENT IND RES (IN) | 2008-03-05 | — | — | CN | disclosed |
| CN-1764663-A | Method for preparing topotecan from 10-hydroxy-4-(S)-camptothecine | COUNCIL SCIENT IND RES (IN) | 2006-04-26 | — | — | CN | disclosed |