Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.66 |
| ▸ | BRAF | P15056 | 6/20 | 0.66 |
| ▸ | RAF1 | P04049 | 7/20 | 0.60 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.60 |
| ▸ | CDK8 | P49336 | 3/20 | 0.58 |
| ▸ | CA7 | P43166 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | MUSK | O15146 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3167291 | 0.87 | KDR (0.74) | KDRBRAFRAF1MAPK3CDK8 | |
| SCHEMBL3174505 | 0.84 | CDK8 (0.71) | KDRBRAFRAF1MAPK3CDK8 | |
| SCHEMBL2763393 | 0.83 | KDR (0.67) | KDRBRAFRAF1MAPK3CDK8 | |
| SCHEMBL2762678 | 0.83 | KDR (0.75) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL4211620 | 0.83 | RAF1 (0.75) | KDRBRAFRAF1MAPK3CDK8 | |
| SCHEMBL2762618 | 0.82 | KDR (0.73) | KDRBRAFRAF1MAPK3CDK8 | |
| SCHEMBL13945963 | 0.82 | KDR (0.74) | KDRBRAFRAF1MAPK3CDK8 | |
| SCHEMBL4211096 | 0.81 | KDR (0.64) | KDRBRAFRAF1MAPK3CDK8 | |
| SCHEMBL2762359 | 0.79 | KDR (0.73) | KDRBRAFRAF1MAPK3CDK8 | |
| SCHEMBL16907486 | 0.79 | KDR (1.00) | KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080552-B2 | Pyrimidyl derivatives as protein kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2011-12-20 | — | — | US | disclosed |
| EP-2102173-B1 | PYRIMIDYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-10-20 | — | — | EP | disclosed |
| US-20100041684-A1 | PYRIMIDYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | HOFFMANN-LA ROCHE, INC. | 2010-02-18 | — | — | US | disclosed |
| EP-2102173-A1 | PYRIMIDYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008077548-A1 | PYRIMIDYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041684-A1 | PYRIMIDYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | MAP3K5, MAP3K1, MAP4K2 | KDR 1270/4885BRAF 47/4885RAF1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.