Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.56 |
| ▸ | TP53 | P04637 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2762411 | 0.77 | MAPT (0.62) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| SCHEMBL2762879 | 0.76 | MAPT (0.58) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| SCHEMBL2762860 | 0.74 | MAPT (0.56) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| SCHEMBL2762753 | 0.74 | MAPT (0.58) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| SCHEMBL2762933 | 0.72 | MAPT (0.59) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| SCHEMBL2762669 | 0.72 | MAPT (0.56) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| SCHEMBL2763423 | 0.71 | MAPT (0.59) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| SCHEMBL1815237 | 0.68 | ADORA1 (0.97) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| SCHEMBL2762862 | 0.67 | MAPT (0.56) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 | |
| Bromide SCHEMBL2762927 | 0.67 | ADORA1 (0.95) | MAPTTP53SMN1; SMN2ADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283832-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2010-10-20 | — | — | EP | disclosed |