Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 6/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551581 | 0.92 | JAK3 (0.43) | JAK3JAK2KDM1AJAK1LRRK2 | |
| SCHEMBL4551034 | 0.86 | JAK3 (0.45) | JAK3JAK2JAK1LRRK2 | |
| SCHEMBL27610003 | 0.85 | LRRK2 (0.48) | JAK3JAK2KDM1AJAK1TYRO3 | |
| SCHEMBL4551805 | 0.84 | JAK3 (0.46) | JAK3JAK2JAK1 | |
| SCHEMBL20320939 | 0.82 | JAK3 (0.40) | JAK3JAK2KDM1AJAK1AXL | |
| SCHEMBL6439881 | 0.82 | JAK3 (0.47) | JAK3JAK2JAK1LRRK2 | |
| SCHEMBL28541188 | 0.82 | POLB (0.46) | JAK3JAK2JAK1AXLLRRK2 | |
| SCHEMBL4551756 | 0.81 | JAK3 (0.41) | JAK3JAK2KDM1AJAK1LRRK2 | |
| SCHEMBL27609700 | 0.81 | JAK3 (0.41) | JAK3JAK2KDM1AJAK1LRRK2 | |
| SCHEMBL27651472 | 0.80 | JAK3 (0.43) | JAK3JAK2KDM1AJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100387598-C | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2008-05-14 | — | — | CN | claimed |
| CN-1694882-A | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2005-11-09 | — | — | CN | claimed |
| CN-100387598-C | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2008-05-14 | — | — | CN | disclosed |
| CN-1694882-A | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2005-11-09 | — | — | CN | disclosed |