Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.66 |
| ▸ | BCR | P11274 | 12/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.66 |
| ▸ | KIT | P10721 | 4/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
| ▸ | CSF1R | P07333 | 1/20 | 0.66 |
| ▸ | YES1 | P07947 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | HCK | P08631 | 1/20 | 0.66 |
| ▸ | FGR | P09769 | 1/20 | 0.66 |
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
| ▸ | SLC25A6 | P12236 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | BRAF | P15056 | 1/20 | 0.66 |
| ▸ | NQO2 | P16083 | 1/20 | 0.66 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL716325 | 0.87 | ABL1 (0.75) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL716318 | 0.86 | ABL1 (0.76) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL717043 | 0.86 | ABL1 (0.67) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL715902 | 0.86 | ABL1 (0.75) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL24199881 | 0.85 | ABL1 (0.77) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL714758 | 0.85 | ABL1 (0.73) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL14286287 | 0.84 | ABL1 (0.74) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL4087640 | 0.84 | ABL1 (0.82) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL27613348 | 0.84 | ABL1 (0.69) | ABL1BCRPDGFRBPDGFRAKIT | |
| SCHEMBL3719554 | 0.83 | ABL1 (0.73) | ABL1BCRPDGFRBPDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100491374-C | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as C-KIT inhibitors | AB SCIENCE (FR) | 2009-05-27 | — | — | CN | disclosed |
| CN-1684959-A | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as C-KIT inhibitors | AB SCIENCE (FR) | 2005-10-19 | — | — | CN | disclosed |