Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.66 |
| ▸ | BCR | P11274 | 15/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714758 | 0.87 | ABL1 (0.73) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL4825993 | 0.86 | ABL1 (0.70) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL4087640 | 0.86 | ABL1 (0.82) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL3719554 | 0.85 | ABL1 (0.73) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL3794413 | 0.85 | ABL1 (0.76) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL714756 | 0.85 | ABL1 (0.76) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL715666 | 0.85 | ABL1 (0.76) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL1096984 | 0.85 | ABL1 (0.75) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL716168 | 0.85 | ABL1 (0.75) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL717529 | 0.85 | ABL1 (0.69) | ABL1BCRPDGFRBHDAC3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100491374-C | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as C-KIT inhibitors | AB SCIENCE (FR) | 2009-05-27 | — | — | CN | disclosed |
| CN-1684959-A | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as C-KIT inhibitors | AB SCIENCE (FR) | 2005-10-19 | — | — | CN | disclosed |