Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213963 | 0.89 | CYP1A2 (0.62) | NPC1SMN1; SMN2KDM4ERAB9ACYP1A2 | |
| SCHEMBL61315 | 0.89 | — | — | |
| Ammonia Solution, Strong SCHEMBL28161848 | 0.87 | — | — | |
| SCHEMBL29452963 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL27929151 | 0.87 | — | — | |
| Potassium SCHEMBL30601771 | 0.87 | — | — | |
| Hydroxyl Radical SCHEMBL28261927 | 0.87 | — | — | |
| Water SCHEMBL28135826 | 0.84 | CYP1A2 (0.58) | NPC1SMN1; SMN2KDM4ERAB9ACYP1A2 | |
| SCHEMBL11580995 | 0.84 | CA1 (0.79) | NPC1SMN1; SMN2KDM4ERAB9ACYP3A4 | |
| SCHEMBL166536 | 0.84 | CA1 (0.79) | NPC1SMN1; SMN2KDM4ERAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100174089-A1 | HETEROARYL ARYL ETHERS | SALTIGO GMBH (DE) | 2010-07-08 | — | — | US | claimed |
| EP-2179989-A2 | Process for the preparation of heteroaryl - aryl ether | Saltigo GmbH (DE) | 2010-04-28 | — | — | EP | claimed |
| US-8592595-B2 | Preparation of (N-heterocyclyl) aryl ethers | SALTIGO GMBH (DE) | 2013-11-26 | — | — | US | disclosed |
| US-20100174089-A1 | HETEROARYL ARYL ETHERS | SALTIGO GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| US-20100152454-A1 | PREPARATION OF (N-HETEROCYCLYL) ARYL ETHERS | SALTIGO GMBH (DE) | 2010-06-17 | — | — | US | disclosed |
| EP-2179989-A2 | Process for the preparation of heteroaryl - aryl ether | Saltigo GmbH (DE) | 2010-04-28 | — | — | EP | disclosed |
| EP-2179988-A1 | Producing (N-heterocyclic) aryl ethers | Saltigo GmbH (DE) | 2010-04-28 | — | — | EP | disclosed |
| US-4411904-A | Diphenylpropanamines, compositions thereof and use thereof | WARNER-LAMBERT COMPANY (US) | 1983-10-25 | — | — | US | disclosed |
| US-4364954-A | NEUROLEPTIC AGENT | WARNER-LAMBERT COMPANY (US) | 1982-12-21 | — | — | US | disclosed |
| US-4292321-A | 1,3,8-Triazaspirodecane-4-ones, pharmaceutical compositions thereof and method of use thereof | WARNER-LAMBERT COMPANY (US) | 1981-09-29 | — | — | US | disclosed |
| US-4218456-A | 1-(4-Fluorophenyl)-4-(1,2,3,6-tetrahydro-4-phenoxy-1-pyridinyl)-butanones | WARNER-LAMBERT COMPANY (US) | 1980-08-19 | — | — | US | disclosed |