Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 4/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939419 | 0.86 | HPGD (0.51) | RAB9APTGER4HPGDAKR1C3AKR1C2 | |
| SCHEMBL27783675 | 0.78 | SCD (0.53) | — | |
| SCHEMBL27654437 | 0.78 | HPGD (0.49) | MAPTNPC1RAB9AGRNSORT1 | |
| SCHEMBL27830493 | 0.76 | GAA (0.48) | PTGER4HPGDAKR1C3AKR1C2GAA | |
| SCHEMBL27830557 | 0.74 | PTGER4 (0.53) | PTGESPTGER4AKR1C3 | |
| SCHEMBL27958380 | 0.73 | GRN (0.42) | MAPTGRNSORT1CASRHPGD | |
| SCHEMBL27849054 | 0.72 | CYP1A2 (0.56) | PTGER4HPGDTP53AKR1C3AKR1C2 | |
| SCHEMBL27830568 | 0.72 | POLB (0.48) | MAPTGRNSORT1HPGDTP53 | |
| SCHEMBL27848902 | 0.71 | AKR1C3 (0.55) | PTGER4AKR1C3AKR1C2L3MBTL1 | |
| SCHEMBL4785326 | 0.70 | CYP19A1 (0.57) | PTGER4HPGDAKR1C3AKR1C2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100558713-C | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2009-11-11 | — | — | CN | disclosed |
| CN-1829698-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2006-09-06 | — | — | CN | disclosed |