Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5641804 | 0.82 | TSHR (0.58) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL8695913 | 0.81 | TDP1 (0.51) | MAPTALDH1A1SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL3794233 | 0.79 | MAPT (0.68) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL363534 | 0.76 | MAPT (0.66) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL358044 | 0.75 | KDM1A (0.57) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL360551 | 0.75 | HTR2C (0.52) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL3787403 | 0.75 | MAPT (0.58) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL29684402 | 0.75 | HTR2C (0.52) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL359320 | 0.74 | HTT (0.51) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL14194196 | 0.73 | MAPT (0.49) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102718775-B | As the Macrocyclic quinazoline derivatives of antiproliferative | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-02-17 | — | — | CN | disclosed |
| CN-102718775-A | Macrocyclic quinazoline derivatives as antiproliferative agents | JANSSEN PHARMACEUTICA NV | 2012-10-10 | — | — | CN | disclosed |
| CN-1794996-A | Macrocyclic quinazoline derivatives as antiproliferative agents | JANSSEN PHARMACEUTICA NV (BE) | 2006-06-28 | — | — | CN | disclosed |