Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | GCK | P35557 | 12/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27616367 | 0.91 | KCNH2 (0.52) | KCNH2GCKPTGS2SLC6A3SLC6A2 | |
| SCHEMBL27635453 | 0.90 | KCNH2 (0.49) | KCNH2GCKPTGS2SLC6A3SLC6A2 | |
| SCHEMBL27616375 | 0.88 | KCNH2 (0.48) | KCNH2GCKPTGS2SLC6A3 | |
| SCHEMBL27635456 | 0.88 | KCNH2 (0.48) | KCNH2GCKOPRM1OPRK1 | |
| SCHEMBL27635457 | 0.88 | KCNH2 (0.48) | KCNH2GCKPTGS2SLC6A3SLC6A2 | |
| SCHEMBL27635458 | 0.87 | KCNH2 (0.50) | KCNH2GCKOPRM1PTGS2SLC6A3 | |
| SCHEMBL27616313 | 0.87 | KCNH2 (0.51) | KCNH2GCKPTGS2SLC6A3SLC6A2 | |
| SCHEMBL27616354 | 0.87 | KCNH2 (0.49) | KCNH2GCKOPRM1PTGS2SLC6A3 | |
| SCHEMBL27635449 | 0.87 | KCNH2 (0.47) | KCNH2GCKOPRM1PTGS2SLC6A3 | |
| SCHEMBL27635452 | 0.85 | KCNH2 (0.51) | KCNH2GCKPTGS2SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100469770-C | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | CN | claimed |
| CN-1726197-A | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2006-01-25 | — | — | CN | claimed |
| CN-100469770-C | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | CN | disclosed |
| CN-1726197-A | 5-substituted-pyrazine or -pyridine glucokinase activators | HOFFMANN LA ROCHE (CH) | 2006-01-25 | — | — | CN | disclosed |