Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.62 |
| ▸ | FLT3 | P36888 | 9/20 | 0.62 |
| ▸ | KIT | P10721 | 7/20 | 0.62 |
| ▸ | ABL1 | P00519 | 7/20 | 0.53 |
| ▸ | BCR | P11274 | 6/20 | 0.53 |
| ▸ | PRKACA | P17612 | 6/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.49 |
| ▸ | CSF1R | P07333 | 5/20 | 0.49 |
| ▸ | PLK4 | O00444 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 5/20 | 0.49 |
| ▸ | FLT1 | P17948 | 5/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.49 |
| ▸ | MARK3 | P27448 | 5/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | FLT4 | P35916 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636462 | 0.91 | KDR (0.60) | KDRFLT3KITABL1BCR | |
| SCHEMBL27636414 | 0.87 | KDR (0.48) | KDRFLT3KITABL1BCR | |
| SCHEMBL28757592 | 0.87 | KDR (0.61) | KDRFLT3KITABL1BCR | |
| SCHEMBL4739562 | 0.87 | KDR (0.74) | KDRFLT3KITABL1BCR | |
| SCHEMBL27657352 | 0.86 | KDR (0.66) | KDRFLT3KITABL1BCR | |
| SCHEMBL4739859 | 0.85 | KDR (0.63) | KDRFLT3KITABL1BCR | |
| SCHEMBL4740070 | 0.85 | KDR (0.62) | KDRFLT3KITABL1BCR | |
| SCHEMBL27636419 | 0.85 | KDR (0.52) | KDRFLT3KITABL1BCR | |
| SCHEMBL3363647 | 0.85 | KDR (0.68) | KDRFLT3KITABL1BCR | |
| SCHEMBL27657299 | 0.85 | KDR (0.65) | KDRFLT3KITABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | claimed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | disclosed |
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | disclosed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |