Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.41 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.41 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.41 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dodecane SCHEMBL27754333 | 1.00 | TSHR (0.50) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Octane SCHEMBL27821579 | 1.00 | TSHR (0.50) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Hexadecane SCHEMBL27934579 | 1.00 | TSHR (0.50) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Pyridine SCHEMBL27689622 | 0.97 | TSHR (0.53) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Hexadecane SCHEMBL27657619 | 0.97 | TSHR (0.53) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Tetradecane SCHEMBL27729242 | 0.97 | TSHR (0.53) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Octane SCHEMBL11323035 | 0.97 | TSHR (0.53) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Dodecane SCHEMBL3262468 | 0.97 | TSHR (0.53) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Heptane SCHEMBL5680251 | 0.97 | TSHR (0.53) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 | |
| Dodecane SCHEMBL28141727 | 0.94 | TSHR (0.50) | TSHRTDP1NAPRTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1790772-A | Patterned substrate, electro-optical device, and method for manufacturing an electro-optical device | SEIKO EPSON CORP (JP) | 2006-06-21 | — | — | CN | disclosed |