Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12590197 | 0.91 | — | — | |
| SCHEMBL97738 | 0.91 | — | — | |
| SCHEMBL4744383 | 0.91 | — | — | |
| SCHEMBL667584 | 0.91 | — | — | |
| SCHEMBL7665622 | 0.91 | — | — | |
| SCHEMBL4228879 | 0.91 | — | — | |
| SCHEMBL18562028 | 0.91 | — | — | |
| SCHEMBL5499838 | 0.91 | — | — | |
| Ammonia Solution, Strong SCHEMBL2337881 | 0.88 | TP53 (0.43) | HDAC1HDAC2TP53FFAR1ALDH1A1 | |
| SCHEMBL17795738 | 0.76 | TP53 (0.41) | HDAC1HDAC2TP53ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102908331-A | Duloxetine hydrochloride enteric capsules and preparation method thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL TECHNOLOGY CO LTD | 2013-02-06 | — | — | CN | disclosed |
| CN-100362997-C | Enteric coated table of duloxetine, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2008-01-23 | — | — | CN | disclosed |
| CN-100362996-C | Duloxetine enteric coated tiny pill capsule, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2008-01-23 | — | — | CN | disclosed |
| CN-1759829-A | Duloxetine enteric coated tiny pill capsule, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2006-04-19 | — | — | CN | disclosed |
| CN-1759830-A | Enteric coated table of duloxetine, and preparation method | SHANGHAI INST OF MEDICINE IND (CN) | 2006-04-19 | — | — | CN | disclosed |