Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.68 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.68 |
| ▸ | KDR | P35968 | 17/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.64 |
| ▸ | PLK4 | O00444 | 6/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.61 |
| ▸ | ABL1 | P00519 | 6/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.61 |
| ▸ | LCK | P06239 | 6/20 | 0.61 |
| ▸ | FYN | P06241 | 6/20 | 0.61 |
| ▸ | CSF1R | P07333 | 6/20 | 0.61 |
| ▸ | LYN | P07948 | 6/20 | 0.61 |
| ▸ | MET | P08581 | 6/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.61 |
| ▸ | FLT1 | P17948 | 6/20 | 0.61 |
| ▸ | FLT3 | P36888 | 6/20 | 0.61 |
| ▸ | BLK | P51451 | 6/20 | 0.61 |
| ▸ | NEK2 | P51955 | 6/20 | 0.61 |
| ▸ | LIMK1 | P53667 | 6/20 | 0.61 |
| ▸ | STK3 | Q13188 | 6/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27640629 | 0.98 | AURKA (0.65) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL27640589 | 0.92 | AURKA (0.75) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL27640532 | 0.91 | AURKA (0.83) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL3529971 | 0.90 | AURKA (0.82) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL27661173 | 0.90 | AURKA (0.72) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL27661226 | 0.89 | KDR (0.69) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL27640578 | 0.89 | AURKA (0.80) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL3534124 | 0.88 | AURKA (0.79) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL28757954 | 0.87 | KDR (0.68) | AURKAALKKDRAURKBPLK4 | |
| SCHEMBL27640549 | 0.86 | KDR (0.68) | AURKAALKKDRAURKBPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103087078-A | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LAB | 2013-05-08 | — | — | CN | disclosed |
| CN-1856498-A | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LAB (US) | 2006-11-01 | — | — | CN | disclosed |