Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.64 |
| ▸ | AURKA | O14965 | 10/20 | 0.63 |
| ▸ | LCK | P06239 | 9/20 | 0.63 |
| ▸ | FYN | P06241 | 9/20 | 0.63 |
| ▸ | CSF1R | P07333 | 9/20 | 0.63 |
| ▸ | MET | P08581 | 9/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.63 |
| ▸ | BLK | P51451 | 8/20 | 0.63 |
| ▸ | STK3 | Q13188 | 8/20 | 0.63 |
| ▸ | ABL1 | P00519 | 8/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.63 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.63 |
| ▸ | NEK2 | P51955 | 7/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.63 |
| ▸ | LYN | P07948 | 6/20 | 0.63 |
| ▸ | KIT | P10721 | 6/20 | 0.63 |
| ▸ | MARK3 | P27448 | 6/20 | 0.63 |
| ▸ | MARK2 | Q7KZI7 | 6/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27640540 | 0.90 | KDR (0.64) | KDRAURKBAURKALCKFYN | |
| SCHEMBL27661139 | 0.90 | KDR (0.64) | KDRAURKBAURKALCKFYN | |
| SCHEMBL3526143 | 0.89 | KDR (0.80) | KDRAURKBAURKALCKFYN | |
| SCHEMBL14633521 | 0.88 | AURKA (0.77) | KDRAURKBAURKALCKFYN | |
| SCHEMBL27661226 | 0.86 | KDR (0.69) | KDRAURKBAURKALCKFYN | |
| SCHEMBL28757954 | 0.84 | KDR (0.68) | KDRAURKBAURKALCKFYN | |
| SCHEMBL27640549 | 0.83 | KDR (0.68) | KDRAURKBAURKALCKFYN | |
| SCHEMBL27661160 | 0.83 | KDR (0.66) | KDRAURKBAURKALCKFYN | |
| SCHEMBL27904959 | 0.83 | AURKA (0.65) | KDRAURKBAURKALCKFYN | |
| SCHEMBL27640630 | 0.83 | KDR (0.71) | KDRAURKBAURKALCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103087078-A | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LAB | 2013-05-08 | — | — | CN | disclosed |
| CN-1856498-A | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LAB (US) | 2006-11-01 | — | — | CN | disclosed |