Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HTR3B | O95264 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27666005 | 0.89 | HRH3 (0.52) | HRH3PDE2APDE1BPDE4DPDE10A | |
| SCHEMBL27644534 | 0.86 | PDE2A (0.52) | PDE2APDE1BPDE4DPDE10A | |
| SCHEMBL27157758 | 0.82 | NPC1 (0.58) | PDE10AKDM4EALDH1A1HTR3AHTT | |
| SCHEMBL2093153 | 0.81 | KDM4E (0.47) | HRH3KDM4EALDH1A1ADRB1 | |
| SCHEMBL2093151 | 0.79 | KDM4E (0.47) | HRH3KDM4EALDH1A1ADRB1 | |
| SCHEMBL2630926 | 0.78 | PDE2A (0.66) | PDE2APDE1BPDE4DPDE10A | |
| SCHEMBL27931272 | 0.78 | PDE10A (0.64) | HRH3PDE10AHTR3EKDM4EHTR3B | |
| SCHEMBL2630880 | 0.77 | PDE2A (0.61) | PDE2APDE1BPDE4DPDE10A | |
| SCHEMBL2631079 | 0.77 | HRH3 (0.65) | HRH3PDE10AHTR3EKDM4EHTR3B | |
| SCHEMBL6701347 | 0.77 | HRH3 (0.65) | HRH3PDE10AHTR3EKDM4EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |