Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27645582 | 0.90 | ERBB2 (0.68) | EGFRERBB2LCK | |
| SCHEMBL5564136 | 0.89 | EGFR (0.61) | EGFRERBB2LCK | |
| SCHEMBL30126660 | 0.85 | EGFR (0.49) | EGFRERBB2LCKEPHA2KDR | |
| SCHEMBL30125772 | 0.85 | EGFR (0.49) | EGFRERBB2LCKEPHA2KDR | |
| SCHEMBL30126610 | 0.85 | EGFR (0.49) | EGFRERBB2LCKEPHA2KDR | |
| SCHEMBL30127111 | 0.85 | EGFR (0.49) | EGFRERBB2LCKEPHA2KDR | |
| SCHEMBL30126547 | 0.84 | EGFR (0.58) | EGFRERBB2LCK | |
| SCHEMBL30127204 | 0.84 | EGFR (0.58) | EGFRERBB2LCK | |
| SCHEMBL30126766 | 0.84 | EGFR (0.58) | EGFRERBB2LCK | |
| SCHEMBL5564700 | 0.84 | EGFR (0.69) | EGFRERBB2EPHA2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882573-A | Quinazoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2006-12-20 | — | — | CN | claimed |
| CN-1882573-A | Quinazoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2006-12-20 | — | — | CN | disclosed |