SCHEMBL27652124

SCHEMBL27652124

COc1nc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(OC(C)CO)c2)sc1C

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.68
KCNH2 Q12809 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3603662 0.84 GCK (0.72) GCKKCNH2
SCHEMBL13255182 0.84 GCK (0.72) GCKKCNH2
SCHEMBL3599394 0.84 GCK (0.67) GCKKCNH2
SCHEMBL3601195 0.84 GCK (0.71) GCKKCNH2
SCHEMBL13255170 0.84 GCK (0.71) GCKKCNH2
SCHEMBL3231097 0.83 GCK (0.83) GCKKCNH2
SCHEMBL3595073 0.83 GCK (0.84) GCKKCNH2
SCHEMBL3239890 0.83 GCK (0.84) GCKKCNH2
SCHEMBL2653537 0.83 GCK (0.73) GCKKCNH2
SCHEMBL3601406 0.83 GCK (0.73) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1777589-A Heteroarylcarbamoylbenzene derivatives BANYU PHARMA CO LTD (JP) 2006-05-24 CN disclosed