Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.35 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SORD | Q00796 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11994370 | 0.84 | CYP1A2 (0.46) | CYP1A2POLBMAP4K4SREBF1SREBF2 | |
| SCHEMBL17000203 | 0.81 | CYP1A2 (0.43) | CYP1A2POLBMAP4K4SREBF1SREBF2 | |
| SCHEMBL28235461 | 0.81 | CYP1A2 (0.43) | CYP1A2POLBMAP4K4SREBF1SREBF2 | |
| SCHEMBL18415133 | 0.81 | CYP1A2 (0.47) | CYP1A2POLBMAP4K4SREBF1SREBF2 | |
| SCHEMBL19846685 | 0.81 | CYP1A2 (0.47) | CYP1A2POLBMAP4K4SREBF1SREBF2 | |
| SCHEMBL14643122 | 0.81 | CYP1A2 (0.43) | CYP1A2POLBMAP4K4SREBF1SREBF2 | |
| SCHEMBL19910242 | 0.76 | CYP1A2 (0.42) | CYP1A2POLBMAP4K4SREBF1SREBF2 | |
| SCHEMBL20960558 | 0.76 | CYP1A2 (0.46) | CYP1A2POLBMAP4K4SREBF1SREBF2 | |
| SCHEMBL11266102 | 0.75 | AKR1C3 (0.50) | CYP1A2POLBKDM4ELMNACYP3A4 | |
| SCHEMBL29256500 | 0.74 | CYP1A2 (0.45) | CYP1A2POLBMAP4K4SREBF1SREBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1768054-A | Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | AVENTIS PHARMA SA (FR) | 2006-05-03 | — | — | CN | disclosed |