Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.71 |
| ▸ | PRAP1 | Q96NZ9 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2763260 | 0.89 | PARP1 (0.79) | PARP1 | |
| SCHEMBL2764771 | 0.88 | PARP1 (0.71) | PARP1 | |
| SCHEMBL2764822 | 0.85 | PARP1 (0.74) | PARP1 | |
| SCHEMBL2765387 | 0.85 | PARP1 (0.76) | PARP1 | |
| SCHEMBL4208087 | 0.84 | PARP1 (0.75) | PARP1 | |
| SCHEMBL5131208 | 0.83 | PARP1 (1.00) | PARP1 | |
| SCHEMBL5125923 | 0.83 | PARP1 (1.00) | PARP1 | |
| SCHEMBL13941832 | 0.83 | PARP1 (0.83) | PARP1 | |
| SCHEMBL2763674 | 0.82 | PARP1 (0.85) | PARP1 | |
| SCHEMBL5125432 | 0.81 | PARP1 (1.00) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176237-A1 | PHTHALAZINONE DERIVATIVES AS INHIBITORS OF PARP-1 | AstraZeneca AB (SE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009004356-A1 | PHTHALAZINONE DERIVATIVES AS INHIBITORS OF PARP-1 | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |