SCHEMBL27655178

SCHEMBL27655178

COc1cc(OC(C)=O)c(C(C)=O)c(O)c1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.59
TNFSF11 O14788 1/20 0.53
LMNA P02545 1/20 0.52
USP2 O75604 1/20 0.46
MAPK1 P28482 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
TSHR P16473 1/20 0.44
MAPT P10636 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA3 P07451 1/20 0.43
PKM P14618 1/20 0.43
CA4 P22748 1/20 0.43
CA6 P23280 1/20 0.43
CA5A P35218 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
CA14 Q9ULX7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9752762 0.81 CYP3A4 (0.78) CYP3A4TNFSF11LMNAUSP2MAPK1
SCHEMBL29664473 0.78 CYP3A4 (0.58) CYP3A4LMNAUSP2MAPK1SMN1; SMN2
SCHEMBL6895045 0.76 TNFSF11 (0.55) CYP3A4TNFSF11USP2MAPK1SMN1; SMN2
SCHEMBL27602532 0.76 TNFSF11 (0.83) CYP3A4TNFSF11LMNASMN1; SMN2TSHR
SCHEMBL21723164 0.76 TNFSF11 (0.83) CYP3A4TNFSF11LMNASMN1; SMN2TSHR
SCHEMBL8928654 0.76 TNFSF11 (0.83) CYP3A4TNFSF11LMNASMN1; SMN2TSHR
SCHEMBL6023659 0.75 CYP3A4 (0.52) CYP3A4TNFSF11USP2MAPK1SMN1; SMN2
SCHEMBL9753021 0.75 TNFSF11 (0.47) CYP3A4TNFSF11LMNAMAPK1SMN1; SMN2
SCHEMBL13601793 0.74 CYP3A4 (1.00) CYP3A4LMNAUSP2MAPK1SMN1; SMN2
SCHEMBL679428 0.74 CYP3A4 (0.68) CYP3A4LMNAUSP2MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1843115-A Use of 2- acetyl-3,4-di hydroxy-5- methoxyphenyl-acetic acid in suppressing growth of hollow grass ZHONGKAI UNIVERSITY OF AGRICUL (CN) 2006-10-11 CN disclosed