Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.59 |
| ▸ | PDE5A | O76074 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
| ▸ | SELE | P16581 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7619103 | 0.87 | EGFR (0.59) | EGFRPDE5AMEN1MAPTKMT2A | |
| SCHEMBL5118446 | 0.83 | PDE5A (0.51) | EGFRPDE5AMEN1MAPTKMT2A | |
| SCHEMBL29360504 | 0.81 | ICAM1 (0.72) | EGFRICAM1SELEVCAM1RAB9A | |
| SCHEMBL7613092 | 0.80 | PDE5A (0.53) | EGFRPDE5AMEN1MAPTKMT2A | |
| SCHEMBL7540185 | 0.80 | PDE5A (0.48) | EGFRPDE5AMEN1MAPTKMT2A | |
| SCHEMBL5128667 | 0.80 | PDE5A (0.52) | EGFRPDE5AMEN1MAPTKMT2A | |
| SCHEMBL5129296 | 0.79 | PDE5A (0.59) | EGFRPDE5AMEN1MAPTKMT2A | |
| SCHEMBL5128786 | 0.79 | PDE5A (0.45) | EGFRPDE5AMEN1MAPTKMT2A | |
| SCHEMBL5124980 | 0.78 | PDE5A (0.44) | EGFRPDE5AMEN1MAPTKMT2A | |
| SCHEMBL5129167 | 0.78 | PDE5A (0.48) | EGFRPDE5AMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875023-A | Use of thienopyrimidines | MERCK PATENT GMBH (DE) | 2006-12-06 | — | — | CN | disclosed |