Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 15/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27885648 | 1.00 | HDAC2 (0.53) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL27676827 | 0.91 | HDAC2 (0.47) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL27676960 | 0.86 | HDAC1 (0.57) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL27656952 | 0.84 | HDAC1 (0.37) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL27725303 | 0.83 | HDAC1 (0.43) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL28770061 | 0.83 | HDAC1 (0.38) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL27725123 | 0.83 | HDAC2 (0.44) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL27704597 | 0.82 | HDAC2 (0.43) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL296490 | 0.79 | HDAC1 (0.65) | HDAC2HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL296489 | 0.79 | HDAC1 (0.65) | HDAC2HDAC1HDAC6HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1926103-B | Sulfonyl pyrroles as HDAC inhibitors | 4SC AG | 2012-12-19 | — | — | CN | claimed |
| CN-101268070-B | Novel sulphonylpyrroles as inhibitors of HDAC novel sulphonylpyrroles | NYCOMED GMBH | 2012-09-05 | — | — | CN | claimed |
| CN-101268070-A | Novel sulphonylpyrroles as inhibitors of HDAC novel sulphonylpyrroles | NYCOMED GMBH (DE) | 2008-09-17 | — | — | CN | claimed |
| CN-1926103-A | Sulfonyl pyrroles as HDAC inhibitors | ALTANA PHARMA AG (DE) | 2007-03-07 | — | — | CN | claimed |
| CN-1926103-B | Sulfonyl pyrroles as HDAC inhibitors | 4SC AG | 2012-12-19 | — | — | CN | disclosed |
| CN-101268070-B | Novel sulphonylpyrroles as inhibitors of HDAC novel sulphonylpyrroles | NYCOMED GMBH | 2012-09-05 | — | — | CN | disclosed |
| CN-101287706-A | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors | NYCOMED GMBH (DE) | 2008-10-15 | — | — | CN | disclosed |
| CN-101268070-A | Novel sulphonylpyrroles as inhibitors of HDAC novel sulphonylpyrroles | NYCOMED GMBH (DE) | 2008-09-17 | — | — | CN | disclosed |
| CN-1926103-A | Sulfonyl pyrroles as HDAC inhibitors | ALTANA PHARMA AG (DE) | 2007-03-07 | — | — | CN | disclosed |