Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297040 | 0.88 | HDAC1 (0.58) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL297039 | 0.88 | HDAC1 (0.58) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL27676949 | 0.85 | HDAC2 (0.57) | HDAC1HDAC3HDAC2HDAC4HDAC9 | |
| SCHEMBL28760066 | 0.79 | HDAC1 (0.47) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL28763316 | 0.77 | HDAC1 (0.62) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL295755 | 0.77 | HDAC1 (0.68) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL295754 | 0.77 | HDAC1 (0.68) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL28763314 | 0.76 | HDAC1 (0.57) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL295189 | 0.76 | HDAC1 (0.45) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL295190 | 0.76 | HDAC1 (0.45) | HDAC1HDAC6HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1926103-B | Sulfonyl pyrroles as HDAC inhibitors | 4SC AG | 2012-12-19 | — | — | CN | disclosed |
| CN-1926103-A | Sulfonyl pyrroles as HDAC inhibitors | ALTANA PHARMA AG (DE) | 2007-03-07 | — | — | CN | disclosed |