Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 5/20 | 0.40 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DCK | P27707 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017198 | 0.88 | NPC1 (0.48) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL4902987 | 0.86 | MAOB (0.50) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL968444 | 0.86 | NPC1 (0.49) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL18015833 | 0.84 | MAPT (0.50) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL4466375 | 0.83 | NPC1 (0.47) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL5102703 | 0.82 | MAPT (0.52) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL27670372 | 0.82 | NPC1 (0.48) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL20642197 | 0.82 | NPC1 (0.48) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL18014742 | 0.81 | NPC1 (0.47) | NPC1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL27611734 | 0.81 | MAPT (0.49) | NPC1ALDH1A1GAAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1816550-B | Indolyl derivatives substituted with a thiazole ring and their use as PPAR modulators | HOFFMANN LA ROCHE | 2010-04-28 | — | — | CN | disclosed |
| CN-1816550-A | Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators | HOFFMANN LA ROCHE (CH) | 2006-08-09 | — | — | CN | disclosed |