Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.52 |
| ▸ | KIT | P10721 | 15/20 | 0.52 |
| ▸ | FLT3 | P36888 | 11/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | BLK | P51451 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 4/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | LTK | P29376 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28757593 | 0.91 | KDR (0.53) | KDRKITFLT3ABL1LCK | |
| SCHEMBL6800761 | 0.87 | KDR (0.60) | KDRKITFLT3ABL1LCK | |
| SCHEMBL5301508 | 0.86 | KDR (0.62) | KDRKITFLT3ABL1LCK | |
| SCHEMBL13372655 | 0.85 | KDR (0.44) | KDRKITFLT3ABL1LCK | |
| SCHEMBL27636362 | 0.85 | KDR (0.58) | KDRKITFLT3ABL1LCK | |
| SCHEMBL422409 | 0.85 | KDR (0.61) | KDRKITFLT3ABL1LCK | |
| SCHEMBL27636423 | 0.85 | KDR (0.60) | KDRKITFLT3ABL1LCK | |
| SCHEMBL28757596 | 0.85 | KDR (0.60) | KDRKITFLT3ABL1LCK | |
| SCHEMBL5306431 | 0.84 | KDR (0.59) | KDRKITFLT3ABL1LCK | |
| SCHEMBL13372660 | 0.84 | KDR (0.67) | KDRKITFLT3ABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |