Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5917511 | 0.79 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2S100A4MEN1 | |
| SCHEMBL27657456 | 0.78 | CA12 (0.43) | MAPT | |
| SCHEMBL3539250 | 0.76 | KDM4E (0.48) | CDK2HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10062975 | 0.73 | MAP4K4 (0.59) | MAP4K4MKNK1MKNK2NOS3NOS1 | |
| SCHEMBL3596326 | 0.72 | CYP2A6 (0.35) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL30968134 | 0.71 | MAP4K4 (0.57) | MAP4K4MKNK1MKNK2NOS3NOS1 | |
| SCHEMBL27401952 | 0.70 | NPC1 (0.47) | MAP4K4MKNK1MKNK2NOS3NOS1 | |
| SCHEMBL27657405 | 0.69 | CYP1A2 (0.44) | MAPK14TGFBR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL295633 | 0.68 | KDM4E (0.57) | HTTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3845483 | 0.68 | MAP4K4 (0.55) | MAP4K4MKNK1MKNK2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1829721-A | Spiro '1-azabicyclo' 2.2.2! octan-3,5'-oxazolidin - 2'-one! derivatives with affinity to the alpha7 nicotinic acetylcholine receptor | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | CN | claimed |
| CN-1829721-A | Spiro '1-azabicyclo' 2.2.2! octan-3,5'-oxazolidin - 2'-one! derivatives with affinity to the alpha7 nicotinic acetylcholine receptor | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | CN | disclosed |