Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.60 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.42 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134573 | 0.87 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1784923 | 0.86 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL27658350 | 0.86 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48455 | 0.85 | PIK3CD (0.75) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL27658380 | 0.85 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL12363422 | 0.84 | PIK3CD (0.80) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49387 | 0.83 | PIK3CD (0.78) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1784085 | 0.83 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1784080 | 0.83 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1783983 | 0.83 | PIK3CG (0.60) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1838953-B | Phosphatidylinositol 3-kinase (PI) for the treatment of inflammatory airway diseases3) Inhibitor 5-phenyl-4-methyl-thiazol-2-yl-amine derivatives | NOVARTIS AG | 2011-02-02 | — | — | CN | disclosed |
| CN-1838953-A | Phosphatidylinositol 3-kinase (PI3) inhibitor 5-phenyl-4-methyl-thiazol-2-yl-amine derivatives for the treatment of inflammatory airway diseases | NOVARTIS AG (CH) | 2006-09-27 | — | — | CN | disclosed |